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Autism Coach

Phosphorylated Serine Plus


Phosphorylated Serine Plus

0.25 LBS

Product Description

The Original Formulation of Seriphos Phosphorylated Serine is Back!

Phosphorylated Serine Plus contains an active, a soy-free, gluten-free, casein-free, vegan form of Phosphatidyl Serine, combined with ethanolamine, phosphate, magnesium, calcium, and phosphorus. Unlike phosphotidyl serine, phosphorylated serine can be absorbed even if there are not adequate enzymes available in the intestinal tract, which is common in autism and other gastro-intestinal related health issues.  Evidence suggests the combination of ingredients in Phosphorylated Serine Plus lowers cortisol (adrenaline) levels and reduces the amount of cortisol released due to stress.*

Phosphorylated Serine is also a key component methylation pathways can help with those with impaired methylation, such as those with genetic mutations on the MTHFR gene, which is estimated to be at least 90% of individuals diagnosed with autism.  Methylation pathways are involved in detoxification, manufacture of neurotransmitters, and switching genes on and off.

Chronic physical and mental stress can desensitize hypothalmic-pituitary-adrenal (HPA) axis and lead to chronically higher levels of cortisol (adrenalin).  The HPA axis is the set of interactions/communications between the glands of the endocrine system (hypothalamus, pituitary gland, adrenal gland) that regulate many body processes.  The body processes the HPA axis regulates includes reactions to stress, digestion, the immune system, moods, sexuality, energy storage and use.  
Cortisol levels fluctuate throughout the day.  Chronically high levels of cortisol can lead to sleep difficulties and anxiety.
When cortisol levels rise at night, depending upon what time they they spike, elevated cortisol can result in either difficulty in going to sleep or waking up in the middle of the night. 
Phosphorylated Serine is a component metabolic processes that naturally convert reduce cortisol levels.  Phosphorylated Serine reduces the pituitary messages (ACTH) that order the adrenal glands to release emergency amounts of cortisol, enhances mood, calms anxiety, and reduces the perception of feeling stressed, helping to increase a perception of well being. 
The phosphorylated serine and ethanolamine in Phosphorylated Serine Plus are both essential building blocks of cell membrane phosopholipids, enhancing membrane integrity and stimulating membrane repair.  It also supports the functions of several important membrane proteins.

In nerve cells, membrane proteins station themselves like sentries along the phospholipid wall, where they perform a variety of important functions necessary for nerve cell message transmission:

  • process enzyme and hormone signals from outside the cell.
  • act as a catalyst for energy production in the mitochondria of nerve cells
  • facilitate the release of neurotransmitters
  • support the functions of the proteins in the neurotransmitter receptors of dendrites
Phosphylated Serine stimulates neuronal plasticity, acting as a compensatory adaptive mechanism to cell deterioration, and is capable of preventing or delaying the decline of neurotransmitter function. 
According to the FDA, "Consumption of phosphatidylserine may reduce risk of dementia in the elderly."
Supporting Normalization of Lipids in the Membranes of Cells and Organs
One of the recent findings concerning autism is that there are abnormalities in the lipids that make up cell membranes, glands and organs, which may be due in part to disruption of the body's ability to produce the building blocks for lipids due to exposure to environmental toxins and other factors.  The building blocks of lipids are found in Phosphorylated Serine Plus can help to restore the integrity of lipids throughout the body. 

It is a naturally occurring good fat, technically, a phospholipid (a fat with a phosphate group attached) and can be found in the membranes of all cells, but it is especially concentrated in the nerve cells of the brain. A cells outer and inner membranes are comprised of a double layer of phospholipid molecules derived from essential fatty acids and other nutrients. It is one of these vital phospholipids.

The phopholipds have a head and two tails (seen below). The heads attract water and the tails repel water and are made of an alcohol and glycerol molecular group. The tails are made of fatty acids. Phospholipds can move around in the cell membrane and allow water and non-polar molecules to pass in and out of the cell. Within the cell membrane layer are also embedded proteins that provide a docking site for the cell to receive and transmit signals, transport molecules in and out of the cell, remove waste products (such as byproducts of energy metabolism, which are toxic to the cell if not removed).

The most abundant class of lipid molecule found in cell membranes is the phospholipid. The phospholipid molecule's polar head group contains a phosphate group. It also sports two nonpolar fatty acid chain groups as its tail. The fatty acid tail is composed of a string of carbons and hydrogens. It has a kink in one of the chains because of its double-bond structure.
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