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Lion's Mane for Neurological Support


Lion's Mane for Neurological Support

0.25 LBS

Product Description

Lion's mane is an edible mushroom that has been used for centuries in traditional Asian cuisine and medicine.  Recent research indicates it may be of benefit for improving memory, increasing alertness and promoting nervous system health. One of the world’s leading mycologists (mushroom biologists), Paul Stamets, is quoted as saying “Lion’s Mane mushroom mycelium is nature’s nutrients for your neurons.”  Because of studies indicating its ability to help repair damaged nerves, Lion’s Mane is being tested and adapted for a variety of treatment areas that include neuropathy, Parkinson’s Disease, and Alzheimers.***  


Preliminary research indicates Lion's Mane may support growth and repair of neurons through stimulating the production of Nerve Growth Factor (NGF), a small protein that is crucial to the growth, maintenance and survival of certain types of neurons. Without NGF, these neurons would undergo apoptosis (cell death). NFG, therefore, plays an essential role of keeping your whole nervous system alive and strong. Not only does NGF keep neurons alive and stimulate the re-mylination of neurons, but it is also shown to stimulate the production of new neurons in your central nervous system, as well as in peripheral nervous system.  

The blood-brain barrier is a semi-permeable membrane that works as a filtering mechanism, carrying blood to the central nervous system. The NGF protein happens to be too large to travel across this membrane, though. However, Lion’s Mane has been shown to be exceptionally active in stimulating the synthesis of Nerve Growth Factor (NGF). It contains substances that stimulate NGF production and pass easily through the blood-brain barrier. One of these substances, called hericenones, actually stimulates the brain to produce more NGF. The other, even more powerful substance is called erinacines. Erincacines is small enough to pass through the critical blood-brain barrier, and can therefore work within the brain to foster NGF production, which in turn boosts the production of new neurons. Understanding of this process is so critical that those who discovered it, Rita Levi-Montalcini and Stanly Cohen, received the 1986 Nobel Prize for Medicine.  Lion’s Mane is well on its way to being a critical element of treatment options related to this process.***

In a 2009 double-blind study in Japan, 50-80 year old men and women diagnosed with mild cognitive impairment were given Lion's Mane.  Those not given the placebo were given 1 gram of Lion's Mane powder 3 times a day for 16 weeks.  At weeks 8,12, 16 and of the trial, group taking the Lion's mane showed significantly increased scores on cognitive function compared with the placebo group, but at week 4 after terminationof the 16 weeks, score decreased significantly.  Laboratory testing showed no adverse effect of taking the Lion's Mane.  The results obtained suggest that Lion's Mane is effective in improving Mild Cognitive Impairment. (Phytother Research, 2009, March 23, (3):367-72). Click here for a link to the citation in 

In another small Japanese study with a randomized sample of 30 women, ingesting lion's mane showed that "HE intake has the possibility to reduce depression and anxiety, and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus." (Nagano et al. 2010).

Recently, mice were injected with neurotoxic peptides in an experiment to assess the effects of lion's mane on the type of amyloid plaque formation seen in Alzheimer's patients. The mice were then challenged in a standard "Y" maze, designed for testing memory. Mice fed with a normal diet were compared to those supplemented with lion's mane mushrooms. As the peptide-induced plaque developed, the mice lost the ability to memorize the maze. When these memory-impaired mice were fed a diet containing 5 percent dried lion's mane mushrooms for 23 days, the beta amyloid placques were significantly reduced and the mice performed significantly better in the Y maze test. Interestingly, the mice regained another cognitive capacity, something comparable to curiosity, as measured by greater time spent exploring novel objects compared to familiar ones. The reduction of beta amyloid plaques in the brains of mushroom-fed mice vs. the mice not fed any mushrooms was remarkable. The formation of amyloid plaques is what many researchers believe is a primary morphological biomarker associated with Alzheimer's. Plaques linked to beta amyloid peptide inflame brain tissue, interfere with healthy neuron transmission, and are indicated in nerve degeneration.

In 2008, Japan’s Tohoku University researched the stimulatory effects of different edible mushroom on NGF in a study reported in the ‘Biological and Pharmaceutical Bulletin’.  Their conclusion was that Lion’s Mane affects the production of enzymes that signal NGF to be released.  Another study in 2009 from the Mushroom Laboratory in Japan, published in ‘Phytotherapy Research’, also determined that it was an effective complimentary treatment for mild cognitive impairment and for best results recommended that it should be used regularly.***

Here is a 2014 video presentation by micologist Paul Stamets on TEDTalks:

Supplement Facts

Serving Size:  2 Capsules

Servings per bottle:  30

Amount per serving:  Organic Lion's Mane (Hericium erinaceous) - 1.1 grams *

*Daily value not established

** Activated mushroom mycellium and fruiting body.

Other ingredients

Vegetarian capsules: pullulen and organic mycellated rice.

*** These statements have not been reviewed by the FDA.  This product is not intended to diganose, prevent, treat or cure any disease.



Kawagishi, H., Ando, M., Sakamoto, H., Yoshida S., Ojima, F., Ishiguro, Y., Ukai, N., Fukukawa, S. 1991. "Hericenone C, D and E, stimulators of nerve growth factor (NGF) synthesis from the mushroom Hericium erinaceum." Tetrahedron Lett 32, 4561-4564.


Ma, Bing-Ji , Jin-Wen Shen, Hai-You Yu, Yuan Ruan, Ting-Ting Wu & Xu Zhao, 2010. "Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus." Mycology: An International Journal on Fungal Biology. 1(2): 92-98.


Mori, K., Inatomi, S., Ouchi, K. Azumi, Y and Tuchida T. 2009. "Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double blinded, placebo controlled clinical trial." Phytother Res. 23:367-372.


Mori, K., Obara, Y., Moriya, T., Inatomi, S., Nakahata, N. 2011. "Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice." Biomed Res. 32(1):67-72.


Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., Ohnuki, K. 2010. "Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake." Biomed Res. 31(4):231-7.


Stamets, P., "Notes on nutritional properties of culinary-medicinal mushrooms." International Journal of Medicinal Mushrooms. 2005; 7:109-116.


Thal, L.J., Kantarci, K., Reiman, E.M., Klunk, W.E., Weiner, M.W., Zetterberg, H., Galasko, D., Praticò, D., Griffin, S., Schenk, D., Siemers, E. 2006. "The role of biomarkers in clinical trials for Alzheimer disease." 20(1):6-15.





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