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Carnosine and Diabetes Research

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There is increasing research that Carnosine protects the eyes not only orally but when taken internally.  The two research papers below indicates that in experiments Carnosine delayed or prevent the onset of diabetes and reduce its severity as well as protecting the eyes from diabetic retinopathy.  There appears to be a genetic abberation individuals who are predisposed to developing diabetes in their metabolism of Carnosine and supplement appears to provide protective benefits.  This includes Native American populations who are more vulnerable to diabetes and appear to carry this genetic abberation in the metabolism of Carnosine.  There are many more articles and research in this are that you can research on pubmed.

Carnosine Delays Onset of Diabetes

 A study published in 2007 at the University of Heidelberg identified a genetic variant (hCN1) that results in increased enzyme activity and is associated with susceptibility for diabetic nephropathy in diabetic patients.  They hypothesized the L-Carnosine represents a critical protective factor.   Carnosine levels were manipulated in a form of knockout mice that are a model of type 2 diabetes. HCN1 cDNA was expressed under the control of a liver-specific promoter in db/db mice, mimicking the expression pattern of hCN1 in humans.  In those mice supplemented with Carnosine, diabetes manifested significantly later and milder. A significant correlation of L-carnosine levels with beta-cell mass was observed.  They concluded that hCN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients.

Diabetes. 2007 Oct;56(10):2425-32. Epub 2007 Jun 29.


Carnosine Prevents Damage to Eyes in Diabetic Retinopathy

A study published in 2011 conducted at the University Medicine Mannheim and University of Heidelberg in Mannheim, Germany has shown that oral carnosine treatment protects the retinal capillary cells in experimental diabetic retinopathy in rats.

Cell Physiol Biochem. 2011;28(1):125-36. Epub 2011 Aug 16.

Link to pubmed citation