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Autism Coach

Bitter Orange Glycerine Extract - 4 oz


Bitter Orange Glycerine Extract - 4 oz

0.03 LBS

Product Description


Bitter orange (citrus aurantium) is used widely to make commercial marmalade.  It has been also been used for thousands of years in Chinese medicine and by natives of the Amazon.  The peel (which is used in the tincture) has anti-inflammatory, anti-bacterial, and anti-fungal properties.  It also contains neurotransmitters p-synephrine alkaloids, octopamine, and tetrahydrobiopterin.   The immature form of the fruit has higher levels of BH4, a key component of metabolic cycles frequently compromised in individuals with polymorphisms on the MTHFR gene and genes related to methylation, detoxification, and sulfation.  It appears to support mitochondrial function by increasing energy production in the body and also appears to improve insulin resistance.  It is also reported to be calming to the digestive tract and can help to promote sleep.*  Our Bitter Orange is a high quality product made in small batches.

When individuals on the autism spectrum have intestinal dysbiosis, pathogenic microbes, yeasts and other pathogens living in the intestinal tract frequently overgrow and produce large amounts of ammonia.  BH4 detoxifies ammonia - and if most of the Bh$ is depleted detoxifying, then it is not available for other processes in the body such as creating neurotransmitters and methyl donors that switch genes on and off, and reduces the production of important antioxidants such as glutathione and super oxide dismutase.  Bitter orange may be a valuable addition to consider enhancing a methylation support protocol.


Commonly Disrupted Metabolic Pathways 2 - 1 of 2.jpg

In studies, Bitter Orange has been shown to increase levels of reduced glutathione, the catalase enzyme and has been shown to contribute to weight loss in numerous studies.  Note that this form of synephrine binds to specific beta 3 Andrenergic sites but does not bind to the beta 1 and 2 adrenergic sites (which can increase risk of heart attack and stroke).  It contains the same form of p-synephrine found in mandarin oranges and clementines - so consuming a glass of orange juice provides about 25 mg of p-synephrine. 

BH4 is a rate limiting molecule that is critical in metabolic processes involving the conversion of amino acids into other forms needed by the body. (3)  In humans, if BH4 is not present, phenylalanine can build up resulting in phenylketonuria, which can result in neurological damage.  BH4 is used as part of treatment for phenylketonuria.  But it is not just phenylalanine that is dependent upon BH4 for conversation.  BH4 is required in several enzymes (aromatic amino acid hydroxylases (AAAH)) that convert aromatic amino acids into forms required by the body:

If there isn't enough BH4, critical amino acids and neurotransmitters are not produced in sufficient levels, and toxic levels of unconverted amino acids and neurotransmitters can build up.  BH4 deficiency can result in excessive levels of phenylalanine and insufficient levels of tyrosine, L-DOPA, dopamine, octopamine, and other neurotransmitters.

Bitter Orange also contains the neurotransmitter, Octopamine, which is deficient in individuals within the autism spectrum.  Octopamine is a neurotransmitter found in humans in the central and sympathetic nervous systems.  Reduced levels of Octopamine cause social deprivation, the inability to communicate, a compromised flight or fight response, and learning disabilities in animals on which experiments have been conducted.  In one preliminary study, parents of autistic children trialed using Bitter Orange and observed improved social awareness, better socialization, and better receptive language. (4)

Bitter orange is frequently combined with weight reducing supplements that include large amounts of caffeine.  In all studies with bitter orange used exclusively with no other additives, it appears to be completely safe.  However, because it contains neurotransmitters it should not be taken in combination with any prescription drugs designed to modify brain chemistry.

Supplement Facts

4 oz bottle.  Recommended dose for an adult is a half a dropper full in a room temperature or cool drink or taken straight.


1.  Hypoglycermic and hypolipidemic effects of neoheperidin derived from citrus aurantisum.

2.  Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells





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