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Autism Coach

Uridine

$27.00

Uridine

$27.00
SKU:
JA-010
Weight:
0.25 LBS
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Product Description

Works with choline to improve fluid intelligence and memory, as well as fight forms of dementia and with EPA/DHA oils to reduce symptoms of depression.

Uridine is one of the four basic components of ribonucleic acid (RNA), which is in many dietary sources such as Beer, Broccoli, Sugarcane extract and Tomatoes. Recent studies show that it works in synergy with Choline (such as Alpha GPC) to help improve fluid intelligence and memory, as well as fights forms of dementia. Other studies suggest that when used with EPA/DHA oils (such as those found in Cod Liver Oil), Uridine may be effective at improving mood and reducing symptoms of depression.*

What Does Uridine Do?

Uridine is a nucleotide that acts as a precursor of brain synapses and membrane phospholipids when used with the omega-3 fatty acid docosahexaenoic acid (DHA) and choline.* It may enhance some brain cholinergic functions.* Uridine also supports the health and function of liver mitochondria.*

According to the developer of nutrigenomic treatment protocol for autism, Dr. Amy Yasko, Uridine has the following properties:

  • Helps to negate mitochondrial toxicitiy
  • Has been been reported to have dramatic effect on social, cognitive,language, and motor improvements in cases of autism.
  • Is important for the maintenance of normal metabolism of nerve cells.
  • Is a pyrimidine. Pyrimidines form RNA which is essential for every learning and memory process.
  • Influences the function and regeneration of nerve cells.

 Does Uridine Work?

Phosphatidylcholine (PC) plays an critical role in brain function by helping cells operate and regulate enzymes, and it is Uridine that increases its synthesis. According to a recent university study, when Uridine is supplemented with a choline source (such as Alpha GPC), phosphatidylcholine synthesis was shown to increase up to 45%.

Uridine may also increases the production of neurites, which are projections from the cell body of a neuron (such as axons where signals leave a neuron and dendrites where neurons receive signals). The more neurites a brain has equates to increased connections and neural signalling, annd thereby, increased cognitive abilities.

Evidence also suggests that Uridine may play a role in increasing the neurotransmitter dopamine, often involved in the reward and pleasure centers of the brain. Higher levels of dopamine can result in improved mood, energy, focus and motivation. It is commonly though that these properties attribute to Uridines anti-depressant & anxiolytic properties

Uridine is also converted to CDP Choline in the brain, thereby increasing the synthesis of Acetylcholine (ACh). Acetylcholine is a key neurotransmitter involved in synaptic plasticity (the brains ability to form, strengthen, weaken, or destroy connections between neurons), which translates to a greater working memory and fluid intelligence.

Possible Uridine Benefits
 
  • Enhance Mood
  • Reduced Stress, Anxiety & OCD Symtoms
  • Enhanced Learning and Memory
  • Improved Fluid Intelligence
  • Modulating/Normalising Dopamine Levels
  • Improved Lipid Membrane Health
Recommended adult dose

One capsule.

Ingredients

Other ingredients: Cellulose, magnesium stearate (vegetable source) and silicon dioxide. Capsule consists of hydroxypropylmethylcellulose.

* The above statements have not been reviewed by the FDA. This product is not intended to treat, cure, or prevent any disease.

References

Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12

Source

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 45 Carleton Street, Cambridge, MA 02139, USA.

Erratum in

  • Neuroscience. 2005;135(2):657.

Abstract

During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key membrane constituents like phosphatidylcholine. Uridine, a normal plasma constituent, can be converted to cytidine triphosphate in PC12 [corrected] cells and intact brain, and has been shown to produce a resulting increase in phosphatidylcholine synthesis. To determine whether treatments that elevate uridine availability also thereby augment membrane production, we exposed PC12 [corrected] cells which had been differentiated by nerve growth factor to various concentrations of uridine, and measured the numbers of neurites the cells produced. After 4 but not 2 days uridine significantly and dose-dependently increased the number of neurites per cell. This increase was accompanied by increases in neurite branching and in levels of the neurite proteins neurofilament M [corrected] and neurofilament 70. Uridine treatment also increased intracellular levels of cytidine triphosphate, which suggests that uridine may affect neurite outgrowth by enhancing phosphatidylcholine synthesis. Uridine may also stimulate neuritogenesis by a second mechanism, since the increase in neurite outgrowth was mimicked by exposing the cells to uridine triphosphate, and could be blocked by various drugs known to antagonize P2Y receptors (suramin; Reactive Blue 2; pyridoxal-phosphate-6-azophenyl-2',4' disulfonic acid). Treatment of the cells with uridine or uridine triphosphate stimulated their accumulation of inositol phosphates, and this effect was also blocked by pyridoxal-phosphate-6-azophenyl-2',4' disulfonic acid. Moreover, degradation of nucleotides by apyrase blocked the stimulatory effect of uridine on neuritogenesis. Taken together these data indicate that uridine can regulate the output of neurites from differentiating PC12 [corrected] cells, and suggest that it does so in two ways, i.e. both by acting through cytidine triphosphate as a precursor for phosphatidylcholine biosynthesis and through uridine triphosphate as an agonist for P2Y receptors.

PMID:
15939540
[PubMed - indexed for MEDLINE]

Link: http://www.ncbi.nlm.nih.gov/pubmed/15939540

Uridine therapy for patients with elevated purine levels

Patent US 6727231 B1 -

Repligen Licenses Patent Rights for Treatment of Mitochondrial Disorders And Purine Autism from University of California, San Diego

Abstract
The invention is based on the discovery that patients having elevated purine levels, e.g., individuals diagnosed with pervasive developmental disorders, such as autistic disorder, and/or neuromuscular disorders, can be treated with uridine compositions.

Links
http://www.google.com/patents/US6727231
http://www.prnewswire.com/news-releases/repligen-licenses-patent-rights-for-treatment-of-mitochondrial-disorders-and-purine-autism-from-university-of-california-san-diego-76203062.html


 

 

 
 

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