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Autism Coach

Low Cholesterol or Slightly Anemic? Pieces of the Autism Puzzle Fall Into Place


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In your child’s medical history (or your medical history) did you receive did blood work indicating low cholesterol or slight anemia (lower levels of red blood cells? This is common in individuals within the autism spectrum and both can reflect underlying conditions that when treated can dramatically reduce or eliminate symptoms of autism.

When Low Cholesterol is not a Good Thing

Proprionic acid lowers cholesterol.  Proprionic acid is also a by-product of Clostridium Difficile, a pathogenic organism commonly found at excessive levels individuals within the autism spectrum. Proprionic acid has also been shown by researchers to trigger symptoms of autism when injected into the brains of rats and is theorized to be a cause of autistic symptoms in humans. Ammonia is another by-product of Clostridium. High levels of proprionic acid are also associated with a condition called Pyroluria, which some researchers theorize may effect up to 50% of people with with autism (I wonder if it is really pyroluria, a genetic condition, or intestinal dysbiosis that results in individuals on the autism spectrum manifesting symptoms identical to that of pyroluria).  Also interestingly, Dr. Ben Feingold, who developed the Feingold diet for individuals with ADD/ADHD, theorized that there was an excess of proprionic acid in individual with ADD/ADHD, and there appears to be a strong overlap in individuals who are diagnosed with Asperger's Syndrome also being diagnosed with ADHD.

A Common Cause of Anemia in Autism

Anemia – B12 is needed to make red blood cells – if there isn’t enough, this can trigger anemia. In order for the small intestine to manufacture B12, it must produce a stomach substance called intrinsic factor – which is believed to be deficient in individuals with autism.

Treatment of B12 Deficiency Triggered Anemia

The forms of B12 that generally work best are those that are in the form the body uses - methylcobalamin and hydroxocobalamin.  The most abosrbable forms are injection, sublingual spray, and liposomal liquids.  B12 works together with B6 and folic acid in many processes in the body, including the methylation cycle.  Once again it is best to use the active, bioavailable forms of B6 (P5) and folic acid (5-MTHF).  These B Vitamins are key to the methylation/detoxification process.  If methylation is impaired, it can lead to a build-up of toxins in the body, impaired liver function, and impaired manufacture of neurotransmitters and impaired and non-typical growth or inhibition of growth of neurons.

Swiss Cheese Disease – Proprionic Acid

 clostridium-difficile.gif

Clostridium Difficile

Proprionic acid is found at its highest concentration in Swiss Cheese which actually has the smell of proprionic acid. It turns out that proprionic acid lowers cholesterol. It is commonly used as a preservative for grains and in dairy products.  Proprionic acid also is a by-product of Clostridia Difficiles, a pathogenic organism commonly found at excessive levels individuals within the autism spectrum. Proprionic acid has been shown by researchers in numerous studies to trigger symptoms of autism when injected into the brains of rats and mice. There is also a genetic condition called proprionic acidemia in which excessive levels of proprionic acid are produced. According to several recent research studies, proprionic acid can alter excitory amino acid receptors. resulting in over stimulation of neurons, leading to neuronal damage and death.

Interestingly, the sweat of men is said to smell more like cheese, while the smell sweat from women is likened to the onion family – perhaps there is more proprionic acid in men than women (which would perhaps be yet another factor in explaining the 4:1 ratio of men to women on the autism spectrum). Proprionic acid is also used as a mold retardant in processed foods, including grain products (such as cereals, breads) and dairy products such as cheeses. High levels of proprionic acid can deplete levels of glutathione. In addition proprionic acid is used to preserve the grain fed to livestock (referred to as Luprosil) which may also result in meat products in our foodchain having higher levels of proprionic acid.  Obviously, proprionic acid should be avoided by most individuals within the autism spectrum and this may provide additional explanation as to why certain foods are not well tolerated.

Recommended Supplements to Treat

In various research studies ranging from the 1970’s to this past year, the following supplements have been found to protect neurons from damage from high levels of proprionic acid which significantly overlaps with what is beneficial for B12 deficiency anemia are:

  • B Vitamins:
    •    Active B12 – methyl and/or hydroxocobalamin generally methyl-B12 works best in injection, liposome form, or sublinqual 
    • Active B6 – P5P
    • Folic Acid – 5-MTHF form
    • Pantothenic Acid, Pantothinc, D-Calcium Pantothenate
  • Magnesium - competes with binding to receptor sites in the brain that cause over-excitement – anti-seizure. Many forms are of benefit:
    • Magnesium sulfate (Epsom salts) - can be absorbed by soaking in a bath with magnesium sulfate or by mixing a teaspoon of Epsom salts into coconut butter and rubbing it into the skin. 
    • Magneisum taurate - easily absorbed, includes taurine, in which individuals with autism are frequently deficient
    •   Magnesium glycinate - magnesium chelated to glycine, a calming neurotransmitter
  • Zinc chelates – more absorbable
  • Oils
    • Omega 3 oils in the form of Cod Liver oil
    •  Omega 6 oils in the form of Coconut oil and coconut milk
  • Amino Acids –
    • Carnitine – removes proprionic acid and promotes detoxification at a cellular level
    • Creatinine - neuroprotectant
    • Taurine - amino acid that acts as calming neurotransmitter, typically at low levels in indviduals within the autism spectrum
    • Glycine - amino acid that acts as calming neurotransmitter
  • Alpha-ketoglutarate and ornithine alph-ketoglutarate – remove ammonia from the brain
  •  Probiotics to compete with and reduce populations of intestinal pathogenic organisms and to normalize metabollic function in the intestinal tract
  • GABA, - calming neurotransmitter
  • Hydroxytryptophan – amino acid and chemical precursor as well as metabollic intermeidate in the making of neurotransmitters serotonin and mealatonin from tryptophan, anti-depressant
  • inositol - Vitamin B8, is also calming - helps to reduce anxiety and enhance sleep
  • Biotin - deficient in individuals with pyroluria
  • Manganese - calming

Just “coincidentally” many of these supplements that have been found to protect the brain against damage against high levels of proprionc acid are exactly the same ones that most widely used within the autism community and have been found to be of greatest benefit by many.  It appears as if excessive levels proprionic acid can alter excitatory amino acid receptors and supplementing with magnesium sulfate can instead bind to these receptor sites, preventing firing of neurons. Also L-Carnitine helps to remove proprionic acid.

Of course, it is best to address the underlying condition contribiuting to high levels of proprionic acid – which appears to be overgrowths of pathogens in the intestinal tract and chronic infections. One of the more promising approachs is that of the biofilm protocols whereby the biofilm (goo) that covers colonies of pathogens in the intestinal tract is stripped away and then the pathogens are killed with anti-fungal, anti-bacterial and anti-viral supplements.

Autism Coach Supplements Recommended For Neurologial Protection from Proprionic Acid

Here is a list of some products Autism Coach carries that can have research studies indicating they protect neurons exposed to high levels of proprionic acid from damage:

  • Methyl Bs – contains methylated forms of B12, B6, B2, and folic acid as well as TMG to promote methylation.
  • Liquid Carnosine Plus – Carnosine provides neurological protection and includes magnesium, taurinate, magnesium glycinate, and magnesium glycinate, and zinc methionine chelate and zinc histindinate chelate
  • Bioactive Vitamin Mineral Powder – Includes active B12, B6, Foliic acid forms, Zinc-glycinate, Vitamin C, Magnesium-glycinate, Manganese, Pantothenic Acid, Inositol
  • Hepa Plus – includes alpha-keto-glutarate; the liver makes most of the glutathione in the body and supporting the liver supports the methylation/.transulfuration pathways important for neurological development and detoxification and optimization of the immune system
  • Multi-Green + - vitamins, minerals, amino acids, enzymes, probiotics in a whole food form that is non-allergenic and well tolerated by individuals with celiac
  • Magnesium-taurate - easily absorbed from of magnesium that includes taurine that is deficient in individuals with autism.
  • Magnesium Glycinate – another absorbable form of magnesium bound to glycine, a calming neurotransmitter
  • Pantothenic Acid -
  • Biotin, B12, Pantothenic Acid provide neuroprotection against excessive levels of proprionic acid. Creatinine, Ginseng, Omega 3, taurine, 500 mg Pantothenic Acid, P5P, chelated zinc
  • B12+B6 spray – sublingual active forms of B12 + B6
  • B12 spray – active B12
  • Active Folate – 5-MTHF – form
  • Theanine – calsm by blocking glutamate receptors and increasing levels of serotonin and dopamine – increases alpha waves in the brain
  • GABA Plus – primary calming/inhigitory neurotransmitter in the brain, depending on individual’s metabolic issues this may or may not be of benefit
  •  Liquid Minerals – include Maganese, Magensium and Zinc

Autism Coach Supplements to Reduce Levels of Organisms that Create Proprionic Acid

Supplements Autism Coach offers to reduce levels of pathogens include:

  • Immunocillin – helps strip away biofilm and simultaneously kill pathogens.
  • Full Spectrum Probiotic Powder – formulated to reduce populations of pathogens common to autism including Clostridia, Klebsiella, and Candida.
  • Green Multi+ - contains a blend of over 20 different probiotics, while gently removing toxins and supporting the liver.
  • Cranberry Extract – suppresses Candida
  • Culturelle – effective against Candida and Clostridia
  • S. Boullardi

References

Links to published research and articles:

http://www.psychology.uwo.ca/autism/

http://imfar.confex.com/imfar/2010/webprogram/Paper6943.html

http://psychology.uwo.ca/pdfs/autism/MacFabe%20etal07.pdf

http://www.greatplainslaboratory.com/home/eng/autismconference.asp

http://www.canada.com/health/Research+making+leaps+bounds+understanding+autism+Partners/5389186/story.html -

http://imfar.confex.com/imfar/2010/webprogram/Paper7162.html

http://www.ncbi.nlm.nih.gov/pubmed/11035315

http://www.jns-journal.com/article/S0022-510X(98)00109-9/abstract

http://autismcalciumchannelopathy.com

http://www.ncbi.nlm.nih.gov/pubmed/16337998

http://www.google.com/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=52&ved=0CCMQFjABODI&url=http%3A%2F%2Fwww.iovs.org%2Fcontent%2F39%2F6%2F972.full.pdf&ei=VGLsTvGSH8qugwf http://www.iovs.org/content/39/6/972.full.pdf to5T2CA&usg=AFQjCNFSr04IYlY0cHQNIETh1sbTcudwKQ