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Glyphosate, Folic Acid, Oxalic Acid, Vaccines, and Tylenol Wreak Metabolic Havoc Together


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Updated March 23, 2017. 

Monsanto's weed killer, Roundup, has poisoned virtually every person in the United States.  The widespread poisoning began in 2000, when genetically modified (GMO) crops were allowed to grown in the United States, with seeds also provided by Monsanto.  Monsanto used genetic modification to render genetically modified crops resistant to Roundup, so it could be used instead of plowing to kill weeds.  Millions of tons of Roundup are now annually sprayed on fields.  Roundup does not break down, it evaporates water and rains down on us. If you live in the United States, you have Roundup in your body.

There are literally thousands of man-made chemicals now in our environment that we are exposed to, many of which are hazardous to our health, but Roundup is especially problematic. Not only is the active ingredient in Roundup, glyphosate toxic, but so are additives in Roundup that render it many more times toxic, including oxalic acid.  In addition, exposure to the combination of Roundup, folic acid (the artificial form of folate), and Tylenol (acetaminophen) create a perfect storm of metabolic disruptors that are implicated not only in triggering the epidemic of autism that has accelerated dramatically since Roundup began to be widely used to grow GMO crops, but a myriad of other chronic health and neurological problems as well.

Dr. Stephanie Seneff, a senior researcher at MIT, has been publishing papers and giving lectures on the danger of glyphosate, and how it profoundly disrupts the body's metabolic processes.  This article explores theories of Dr. Seneff and her colleagues.

 2000 - The Year GMO Crops and Widespread Use of Roundup Contaminated the Food Supply

Ninety percent of the GMO crops (GMO corn, soy, cotton, sugar beets, and canola) grown in the U.S. are engineered to be “Roundup Ready,”  - they can be sprayed with Roundup and will not be killed, instead they soak up Roundup into their tissues. The practice of drying out crops like wheat and sugar cane just before the harvest by spraying them with Roundup is also becoming more and more popular as a way to reduce the amount of vegetation that needs to be cleared before planting next year’s crop. Roundup is entering our food supply in record amounts. And most suburban home owners, obsessed with maintaining their neighborhood's expectation of a perfect monoculture lawns, freely douse their yards with Roundup to fight weeds, as do their lawn services.

According to Monsanto (the manufacturer of Roundup), Roundup kills weeds by interfering with what is called the shikimate metabolic pathway. This pathway is essential in plants for the synthesis of a class of amino acids called the “aromatics.” This metabolic pathway is not used by mammals (such as humans) but is used by bacteria, probiotics and plants.  

While people don’t possess the shikimate pathway, all of the microbes that take up residence in our digestive tract do have this pathway, and exposure to glyphosate, the active ingredient in Roundup, will cause them serious stress as a consequence. Studies have shown that glyphosate disrupts the gut bacteria in chickens, cows, and pigs, causing inflammation in the gut along with an overgrowth of pathogenic forms and concurrent loss of beneficial bacteria. Our gut bacteria, which outnumber our own cells by a factor of ten to one, play many important roles in supplying nutrients and protecting us from toxins. The brain and digestive tract communicate with each other constantly - both contain neurons, share neurotransmitters and other molecules.  An unhealthy digestive system directly impacts brain development and function.  A study involving nearly three thousand children with autism spectrum disorder (ASD) found that a quarter of them suffered from chronic gastrointestinal problems like constipation, diarrhea, and bloating; this same group had also significantly higher rates of anxiety and over-sensitivity to sensory stimulation.

Plants and microbes use the shikimate pathway to produce the aromatic amino acids: tryptophan, tyrosine and phenylalanine.  Because people (and other mammals) don’t have this pathway, we can’t produce these essential nutrients, and therefore we depend on plants and microbes to provide them for us.  Glyphosate interferes with these pathway, leading to deficiency in these nutrients. These amino acids are needed to make our brains neurogransmitters.  Tryptophan is needed to make serotonin and melatonin.  Serotonin deficiency is implicated in autism, obesity, Alzheimer’s disease, depression, suicide, and homicidal behavior.  Serotonin is an appetite suppressant so it’s hard not to overeat when it is in short supply. If you are disciplined to resist these urges, then you run the risk of depression and Alzheimer’s disease, or autism in your children. Serotonin is the precursor to melatonin, the neurotransmitter that regulates the wake-sleep cycle, and melatonin deficiency is also implicated in autism.  Tyrosine is needed to make the neurotransmitter dopamine; impaired dopamine supply is the key defect associated with Parkinson’s disease. Glyphosate activates an enzyme called phenylalanine ammonia lyase (PAL), which breaks down phenylalanine and releases ammonia as a by-product. Excess ammonia in the blood stream can trigger a cascade of metabolic dysfunction in the brain leading to seizure disorders and other neurological issues.

According to Dr. Seneff, intestinal pathogens Clostridia difficile (C. diff ) and Pseudomonas aeruginosa tend to overgrow in the intestinal tract that has been compromised with Roundup. Pseudomonas is among the very few bacterial forms that can metabolize glyphosate; however, one of the molecules it breaks glyphosate down into is formaldehyde, a known carcinogen and neurotoxin.  Formaldehyde is less harmful than glyphosate, but still quite harmful.

Clostridium difficle frequently overgrows in the intestinal tracts of people exposed to Roundup and produces a toxic phenol called p-Cresol.  P-Cresol is found in the urine in of individuals diagnosed with autism but not in the urine of neurotypical individuals.  Dr. Seneff theorizes p-Cresol inteferes with sulfate metabolism.  Individuals with autism have been found to have only one third as much free sulfate in the blood as their normal peers. The essential sulfur-containing amino acid, methionine, is a source of both sulfur and methyl groups to the body, both of which are crucial for normal brain development.  

The sulfate molecule, heparan sulfate is also depleted in individuals with autism.  Heparin Sulfate is a sulfur-bearing molecule which is critical for cellular membrane function, cellular communication, the delivery of nutrients for most of the body’s cells, and is essential for brain development.  A loss of heparan sulfate in the gut lining results a leaky gut - if proteins from food leak through the gut, this frequently triggers an autoimmune response resulting in allergies to proteins such as gluten and casein, common in autism. Mice engineered to be impaired in heparan sulfate synthesis in the brain exhibit all of the features of autism. Flavonoids in brightly colored vegetables and fruits and in compounds like resveratrol and curcurmin are beneficial phenolic compounds that have antioxidant properties - and they all safely transport sulfate.  However, if sulfate metabolism is disrupted, and a phenolic compound does not get re-sulfated, the phenolic compound can become a reactive molecule causing oxidative stress, damaging tissues throughout the body.  Sulfation is critical to preventing phenolic compounds from becoming and staying toxic.  It turns  out that other molecules that help to transport sulfur and prevent oxidative stress are also frequently depleted by glyphosate including:  Vitamin D3, dopamine, serotonin, and norephinephrine.  

Around the year, 2000, three major GMO crops that tolerant of Roundup were allowed to be planted on a massive scale in the United States - corn, soy, and cotton. Over 90% of all of these crops are now GMO and grown with Roundup.  There is a directly correlation between the increase of autism and the increased growth of crops that depended on Roundup:

autism-prevalence-2-6-year-olds.jpg

The main active ingredient in Roundup is glyphosate.  Monsanto has argued glyphosate is harmless to humans because our cells don't have a metabolic pathway called the shikimate pathway, which Roundup inhibits; this is how it kills weeds.  HOWEVER, the beneficial bacteria in our gut DO use this pathway - and they help to digest our food and provide amino acids and other nutrients we require.  On top of this other ingredients in Roundup greatly increase the effects of glyphosate's toxic effects.

The main toxic effects of glyphosate are:

  • Kills beneficial gut bacteria and allows pathogen to overgrow in the gut.  Amongst the many functions of beneficial gut bacteria are that they help us make and absorb B vitamins and break our food down into the amino acids our cells use to do their work, to make enzymes and other proteins that do work in our body.
  • Interferes with function of cytochrome P450 enzymes.  This family of enzymes detoxifies our food, rendering it safe for us to consume.  Our food poisons us if these enzymes are missing or impaired.
  • Binds to minerals we need for metabolic processes rendering us nutrient deficient such as iron, cobalt, and maganese.
  • Interferes with our body making and using aromatic amino acids tyrosine, tryptophan, and methionine.  These amino acids are essential for making several neurotransmitters in our body such as L-DOPA, melatonin, seratonin, epinephrine, and norepinephrine.  They also are used to make the thyroid hormone, thyroxine.
  • Disrupts our body synthesizing and transporting sulfates.
  • Mimics the amino acid, glycine, altering and/or silencingthe functions of proteins that are normally made with glycine

Scientists believe the body has 135 major metabolic pathways in the body.  Metabolic pathways are a series of steps that produce chemicals the body needs to function.  Every step in a metabolic pathway has a molecule that an enzyme that helps a molecule to transform into the next molecule in the pathway.  If one of the enzymes in a pathway is missing or doesn't work properly, the entire pathway is disrupted.  Metabolic pathways also interact with other pathways - so if one pathway is disrupted that produces a molecule needed for another pathway, then the second pathway is disrupted.  Pretty soon you have several disrupted pathways that aren't working as they normally would.

The end result of disrupted pathways in autism is typically:

  • disrupted gut bacteria
  • intestinal inflammation
  • deficiency of methionine, tyrosine, and tryptophan
  • deficiency of Vitamin D
  • impaired functioning of the methylatransferase enzyme used in methylation processes; one important function of methylation is to turn genes on and off in cells
  • deficiency of calming and mood elevating neurotransmitters such as GABA, Glycine, melatonin, seratonin, epinephrine, norephinephrine, L-DOPA
  • excessive levels of the excitatory neurotransmitter, glutamate, which cause neurological damage
  • hypothyroidism due to insuffiency of thyroxine
  • not enough sulfur, zinc and magnesium - too much copper and heavy metals
  • excessive levels of neurologically toxic metabolic by-products of metabolism such as ammonia and proprionic acid
  • depletion of BH4, a critical activator of several enzymes used in metabolic processes throughout the body including the synthesis of calming neurotransmitters
  • high levels of oxalic acid

For example, glyphosate binds to (chelates) the mineral, manganese.  A deficiency of manganese causes:

  • disrupted gut bacteria - leading to fewer calming neurotransmitters being produced leading to anxiety
  • impaired synthesis of dopamine - leads to thyroid disease and Parkinson's (which individuals with autism are at a much higher risk for developing later in life)
  • excessive levels of glutamates and ammonia in the brain causing neurological damage
  • damage to mitochondria in cells that produce the body's energy

Glyphosate disrupts the body's ability to distribute minerals safely, causing some areas of the body to get too much of a mineral and others to be deficient.  Disruptions in mineral distribution are found in autism, ADHD, Alzheimer's, and Parkinson's.

Glyphosate and Folic Acid

Another man-made product that interacts with glyphosate in our body is folic acid which is supposed to act like the folate our body produces, but in fact is a health hazard.  Folic acid is more stable than the methylated form of folate and has a longer shelf life, hence its popularity in processed foods and an additive to fortified grains such as wheat flour.  An deficiency in folate during pregnancy can lead to birth defects such as spina bifida.   Folate is required to convert homocysteine to methionine.  Homocysteine converts to methionine using the methyltransferase enzyme, B12, zinc, B6, and methyltetrahydrofolate. However, if there is too much ammonia in the body due to overgrowths of pathogens in the gut (due to Roundup),  then there is also too much nitrous oxide produced and this disrupts this metabolic path, causing excessive methylation (adding of methyl groups) to molecules instead of producing much needed molecules of glutathoine, taurine, and sulfate. 

Because folic acid is not natural, it requires extra energy to process and frequently excessive levels of folic acid build up which can't be used by the body.   A major problem with folic acid is that it is NOT methylated, making it stable but it is missing four hydrogen ions (charged hydrogen atoms) and has to be converted to folate to be used by the body.  Excess folic acid, which is more likely to accumulate in the body if the methyltransferase (MTHFR) gene is not working properly, depletes the body of  BH4, an activator molecule that is critical to the workings of several enzymes in the body, including those involved with producing calming neurotransmitters.  Low BH4 in cerebrospinal fluid is linked to autism - with one study showing that children with autism had 42% less BH4 than neurotypical children. 

In one study, high folic acid consumption lead to pseudo-methyltransferse (MTHFR) deficiency, reduced the methylation capacity in the liver, reduced a critical enzyme for producing bile acid (required for digestion), caused liver damage and fatty liver disease.(1)

Another impact of glyphosate is increasing the levels of oxalic acid.  In one study autistic children had three times the levels of serum and urinary oxalic acid than neurotypical children.(2)  Oxalate crystals in the bone marrow may crowd out the bone marrow, leading to anemia and immunosuppression.  There is a directly correlation between the use of glyphosate and increased levels of anemia in the U.S. population:

 

Injury to the brain and other organs could result from oxalate cyrstal deposits in small vessells in the brain and other organs.  It turns out the Monsanto ADDS oxalic acid to Roundup to improve its efficacy in killing weeds.  This renders Roundup even more toxic to humans causing glyoxylate which results in glycation (the bonding of excessive levels of sugar to tissues in the body causing extensive damage to tissues throughout our body).  Oxalate can work with glyphosate and folic acid to cause iron deficiency.

Red blood cell detoxification is significantly impaired by glyphosate. Glyphosate has been shown to significantly reduce G6PD expression in test animals and bacteria.(8) A deficiency of the enzyme, G6PD, deficiency leads to anemia and anemia leads to low oxygen low which leads to dysfunction in the brain linked to autism:

Children with autism may be low in iron but they also have low levels of transferrin, which protects from oxidative damage due to free iron in cells. (3)  It is generally not recommended that children with autism receive an iron supplement as the iron can bind to biofilms in the gut, worsening intestinal infections.  Pernicious anemia can be also caused by low B-12 vitamin levels and so testing of B-12 levels first and supplementing with active forms of B-12 (methylcobalim, hydroxocobalamin, adenosylcobalamin) if need is indicated are recommended to be tried first when attempting to treat anemia.

 Glyphosate and Vaccines

Glyphosate heavily contaminates vaccines. It promotes the overgrowth of pathogens like Clostridium difficle in the gut, leading to leaky gut syndrome. C. Dif produces p-cresol which promotes aluminum uptake by cells, and is a known biomarker for autism.  Glyphosate cages aluminum in vaccines to enable it to promote entry into the brain by promoting calcium uptake, enabling aluminum to gain entry to the brain as a calcium mimic.

Glyphosate suppresses melatonin synthesis by killing off microbes that help to produce the amino acid tryptophan that is the precursor to melatonin and seratonin.   Melatonin binds to aluminum, cadmium, copper, lead, and iron, reducing their toxicity.  It is produced by the pineal gland regulates and promotes sleep.  Deficiency of serotonin is linked to autism, obseity, depression, Alzheier's, and violent behavior.  Insomnia occurs more frequently as an adverse reaction to vaccines containing aluminum than those not containing aluminum.  (4, 5, 6, 7)

Insomnia is strongly correlated with glyphosate usage:

The unfortunate synergistic combination of glycine and vaccines has led to a dramatic increase in vaccine reactions and autism:

Vaccine Reactions to the MMR Vaccine before and after 2002 have changed, likely due to exposure to Roundup.  Many of these reactions are characteristics of symptoms of allergies to monosodium glutamate (MSG).  Glutamate is an additive in vaccines (including flu vacines, MMR, rabies and Varicella (chicken pox).  Glyphosate prevents glutamates from being broken down leading to excessive levels in the body and brain:

Glyphosate, Vaccines and Tylenol

Glyphosate also interferes with the metabolism of Tylenol (acetominophen).   Dr. Seneff theorizes that glyphosate disrupts the CYP enzyme that detoxifies Tylenol. In the May 2008 issue of the journal, Autism, Schultz reported an association between autism and Tylenol, when given to chlidren after having an adverse reaction to the MMR vaccine, generally administered between the ages of 12 and 15 months.  Chlidren who received Tylenol were much more likely to become autistic than those given Advil (ibuprofen). (9)  Not only does glyphosate deplete the neuroprotective antioxidant glutathione, but Dr. Seneff theorizes that CYP enzyme that detoxifies Tylenol is largely deactivated by glyphosate.  Inflammation provoked by tylenol can lead to overproduction of the immune system's cytokines proteins, an excess of cytokines is called a cytokine storm - which can result in an autoimmune attack of the body's own tissues which is implicated in development of autism.

In Summary

Glyphosate in Roundup in combination with oxalic acid (used in Roundup), folic acid that is used to fortify processed foods and grains, vaccines, and tylenol all create a perfect storm of metabolic disruption that have in large part contributed to the skyrocketing rates of autism, as well as a myriad of other neurological and health conditions.

References

1.  KE Christensen e tal., Am J Clin Nutri 2015; 101:646-58.

2.  J Konstantynowic et al., European Jouranl of Paediatric Neurology 16(5), 2011, 485-491.

3.  A Chauhan et al., Life Sciences 2004; 75:2539-2549

4.  N. de Maria et al., J Agric Food Chem 2006, 54, 2621-2628

5.  J. Limson et al. J. Pineal Res. 1998; 24:15-21

6.  S. L. Connors et al., Plasma Serotonin in Autism, Pediatric Neurology 35(3), Sep 2006, 182-186.

7.  Seneff at al., Entropy 2012, 14, 22227-2253

8.  Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies.  Anthony Samsel, Stephenie Seneff.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/

9.  Did Acetominophen Provoke the Autism Epidemic?  Peter Good.  http://www.altmedrev.com/publications/14/4/364.pdf

10. Roundup:  The "Nontoxic" Chemical that May Be Destroying our Health.  Dr. Stephanie Seneff.  https://www.westonaprice.org/health-topics/environmental-toxins/roundup-the-nontoxic-chemical-that-may-be-destroying-our-health/