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New Brain Research

Implications for Autism

by Sue Bennett

With fascination, I recently read Scientific American's September 2003 special issue on the brain.   This special issue of Scientific American focuses on new research that could lead to repairing the brain, previously thought impossible.  In this article, I attempt to tie together some of the information from Scientific American that is relevant to autism.  This is followed by my thoughts on how the new data provided by this research could apply to autism and its treatment.

Several of the articles state that much of the new brain research could lead to new treatments for autism, Parkinson’s and Alzheimer’s.  One area of the brain implicated in playing an important part in all of these diseases is the hippocampus.  The hippocampus is an area of the brain critical for both remembering new information and making new brain cells (and memories).  The hippocampus is located next to the olfactory bulb that processes smells.  Interestingly, one of the early signs of Parkinson’s is a reduced sense of smell – there is also a high incidence of Parkinson’s in rubber workers, such as those people who work in tire manufacturing plants – where the strong smell of rubber often causes workers to lose their sense of smell over time.  Also, many children with Asperger’s Syndrome are hyper-sensitive to smells – which makes one wonder if there is a connection. 

The hippocampus is also subject to damage by chronic stress – including initial research indicating stress experienced by pregnant animals may effect the development of the fetus’s hippocampus in the womb, resulting in a smaller than normal hippocampus.  Chronic stress after birth may also cause the hippocampus to shrink, possibly causing fewer than normal brain cells to be produced.  Research also indicates that chronic stress also causes stronger neurological circuitry to be developed and more easily triggered relating to the flight or fight response, diverting development from the higher areas of thinking and reasoning, such as the prefrontal cortex, those areas that are typically not as well developed and connected in autism.

Interestingly, the hippocampus produces double the number of brain cells with regular exercise session of an hour a day.  Also, exercise seems to help protect against Alzheimer’s.   

There was also an article in this issue on brain plasticity (the ability of the brain to change) and Fast Forward, an intensive computer program designed to improve auditory processing and reading by a pioneer in the theory that the brain’s circuitry can be changed through mental exercise.  This theory does seem to be gaining more credibility through corroborating research that indicates that MRIs of brain patterns in stroke patients change after rehabilitative therapies.  The key to rewiring the brain appears to partially be having the therapy take at least 2-4 hours for at least two weeks – under these conditions, MRIs  show a change in areas of the brain that are used to complete tasks - or to take on new tasks previously accomplished by a now damaged part of the brain.  Frequently, after a stroke that impairs language, the  language processing is taken on by the music processing area of the brain.

The most astounding example of brain recovery is the actor, Christopher Reeves, who years after being paralyzed in a horseback riding accident, is now regaining the ability to move his fingers and push with his legs through intensive physical therapy, where his limbs were moved for him.  Similarly stroke patients are now regaining use of limbs not operable for years by temporarily immobilizing the limbs that are working on the opposite side of the brain and providing an intensive therapy with the paralyzed limbs.  Also, with musicians who have had strokes, exercising fingers individually after a stroke helps to retrain the neurological map in the brain to allow independent control of fingers again. 

What are the implications of the data emerging from this latest research for our children within the autism spectrum and how can we make use of it? Here are my thoughts:

1.  The good news is that children and even adults can develop new neurological pathways that take on new functions within the brain.  With  effective therapies, we should be able to help our children build new abilities in areas such as language, social skills and reasoning.  

2.   Therapies that target areas of deficit that are consistent, repetitive (until a task is mastered) and intensive (take place several hours a week) can begin to create new neurological pathways in the brain in just two weeks.  In stories of miraculous breakthroughs for children with a disability (such as Helen Keller learning to speak or Catherine Maurice's children who have recovered from autism), the breakthroughs occurred when the child received an intensive amount of one-on-one therapy from one or more adults.   

3.  Therapies that are inconsistent, change from week to week and/or are only done a few minutes or a few times a week typically do not result in profound improvements in levels of functioning or the development of new abilities. 

4.  Make sure the child gets exercise every day (preferably 1 hour a day) to reduce stress and create an optimal amount of brain cells to foster greater neurological development.  (I would recommend including exercises that are bilateral - using both the right and left sides of the body.   Bilateral exercise stimulates cross-communication between the left and right hemispheres of the brain.  Bilateral exercises include walking and swinging the arms simultaneously, running, biking, swimming jumping jacks, and windmill toe touches.)

5.  Keep the child’s stress level at a minimum!  This improves memory,  protects the brain, and promotes greater use of higher level reasoning areas of the brain.

In addition to the research mentioned above, other Scientific American articles in this issue discussed research into new drugs that will enhance and protect memory, and research into regenerating the brain.  There is much for us to hope for in finding new treatments and possibly even a cure for autism.